Dexamethasone for Post-cesarean Delivery Pain

• Status: Completed
• Trial end date: 2016-09-21
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to compare post-cesarean section consumption of pain medication between two groups of patients undergoing scheduled cesarean section at term gestation who receive a single-dose of intraoperative steroid (dexamethasone 8 milligrams) versus placebo at 24 hours after surgery. The hypothesis is that a single perioperative dose of dexamethasone 8 mg will significantly reduce postoperative opioid consumption at 24 h in women having cesarean delivery under spinal anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• American Society of Anesthesiology (ASA) class 1, 2 and 3

• Gestational age > 37 weeks

• scheduled for elective cesarean delivery

• spinal or combined spinal epidural anesthesia

• 18 years or older

• speak English

Exclusion Criteria:

• BMI > 45 kg/m2

• Diabetes Mellitus (Type 1, 2 and gestational)

• mild or severe preeclampsia

• history of intravenous drug or opioid abuse

• previous history of chronic pain syndrome

• history of opioid use in the past week

• receipt of an antiemetic within 24 h prior to surgery

• Non-English speaking