Dexamethasone for the Prevention of Postoperative Cognitive Dysfunction

• Status: Completed
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to evaluate the possible effect of dexamethasone on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing to surgery under general anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo
• Collaborators: Duke University; Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Anesthetics; BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• patients over 60 years,

• underwent surgery for inguinal hernia repair, Nissen procedure, cholecystectomy or other surgeries midsize under general anesthesia and hospital stay expected within 72 hours.

Exclusion Criteria:

• age less than 60 years,

• history of brain disease or dementia, other psychiatric disorders that affect cognition,

• lack of proficiency in Portuguese,

• use of corticosteroids or opioid preoperatively.