Dexmedetomidine Combined With Hydromorphone in Tonsillectomy and Adenoidectomy

• Status: Completed
• Trial end date: 2019-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Tonsillectomy and adenoidectomy is one of the most common pediatric surgeries, and agitation and severe postoperative pain have been considered a very common complications. Dexmedetomidine mainly inhibits the release of norepinephrine by acting on the α-adrenergic receptor of the brainstem nucleus, which can produce good sedative effects. Hydromorphone has a longer duration of action than fentanyl, and it also has a certain sedative effect. The combination of the two is more conducive to the management of postanesthetic agitation and pain. This study was to compare the effect of different doses of dexmedetomidine combined with hydromorphone in the sedation and analgesia after pediatric tonsillectomy and adenoidectomy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Eye & ENT Hospital of Fudan University
• Treatments: Dexmedetomidine; Hydromorphone

Criteria

Inclusion Criteria:

• experienced tonsillectomy and adenoidectomy

• ASA physical status I-II

• weight 12-30 kg

Exclusion Criteria:

• respiratory disease

• circulatory or nervous system disease

• hepatic dysfunction

• known adverse reactions to hydromophine and dexmedetomidine