Dexmedetomidine Combined With Lidocaine Infusion Affect Inflammation Cytokines
Status:
Recruiting
Trial end date:
2021-01-12
Target enrollment:
Participant gender:
Summary
Objective: The present study was to evaluate the effects of dexmedetomidine alone, lidocaine
alone and their combined infusion on postoperative inflammation cytokines after Laparoscopic
hysterectomy.
Methods: Investigators enrolled 160 women with American Society of Anesthesiologists (ASA)
physical status I and II, aged 40-65 years, and scheduled for elective laparoscopic
hysterectomy with general anesthesia from October 2017 to August 2018. The participants were
randomly assigned into four groups(n=40 each group): group CON received normal saline
infusion, group LIDO received lidocaine infusion (1.5 mg/kg loading, 1.5 mg/kg/h infusion),
group DEX received dexmedetomidine infusion (0.5 µg/kg loading, 0.4 µg/kg/h infusion) and
group LIDO+DEX received lidocaine (1.5 mg/kg loading, 1.5 mg/kg/h infusion) and
dexmedetomidine infusions (0.5 µg/kg loading, 0.4 µg/kg/h infusion). The four groups received
an IV bolus infusion of normal saline, lidocaine, dexmedetomidine and lidocaine combined with
dexmedetomidine respectively, over 10 minutes before induction of anesthesia, followed by a
continuous IV infusion of normal saline, lidocaine, dexmedetomidine and lidocaine combined
with dexmedetomidine until abdominal wound closure, respectively. Interleukin-6 and tumor
necrosis factor-α levels in serum were measured at different time points: before
administration of drugs (T1), the end of surgery (T2), postoperative 2 hour (T3) and
postoperative 24 hour (T4).
Phase:
N/A
Details
Lead Sponsor:
Anqing Municipal Hospital
Collaborator:
The First Affiliated Hospital of Anhui Medical University