Dexmedetomidine Combined With the Closed Loop of Target Controlled Infusion of Propofol for Anesthesia With Intraoperative Wake up

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The study designed to explore the efficacy and safety of the closed loop of target controlled infusion dexmedetomidine combined with propofol for anesthesia with intraoperative wake up.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Affiliated Hospital of Xi'an Jiaotong University
• Treatments: Anesthetics; Atracurium; Cisatracurium; Dexmedetomidine; Propofol; Remifentanil

Criteria

Inclusion Criteria:

• Written informed consent.

• Ongoing brain functional area surgery with intraoperative wake up.

• American Society of Anesthesiologists class I to II.

• Aged between 18 and 65 years old.

• Weight between plus or minus 20% of the standard weight. Male: (height cm - 80) × 70% = standard weight Female: (height cm - 70) × 60% = standard weight

Exclusion Criteria:

• History of hypertension.

• Serious heart,brain,liver,kidney, pulmonary, and endocrine disease or serious infection.

• Mental disability or mental disease.

• Use of sedative drug.

• Suspected or confirmed long term use of narcotic analgesics.

• Inability to exchange.

• Suspected or confirmed difficult airway.

• Suspected of malignant hyperthermia.

• Neuromuscular disease.

• Allergic to investigational products or with other contraindication.

• Subjects who are breastfeeding or pregnant.

• Participated in other study within 30 days .