Dexmedetomidine Effect on Mitochondrial Function

• Status: Unknown status
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that in addition to a known sympatholytic effect, intraoperative dexmedetomidine reduces adverse changes in mitochondrial function and structure attenuating ischaemia-reperfusion and end-organ injury for children with non cyanotic congenital heart defects having corrective heart surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Hospital for Sick Children
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• aged between 3 - 36 months

• having primary corrective heart surgery

Exclusion Criteria:

• recent surgery (< 3 months)

• previous chemotherapy

• previous transfusion of blood products

• neurodevelopmental disorders (including Trisomy 21)

• supplemental oxygen requirement (< 3 months)

• asthma requiring regular therapy

• obstructive sleep apnea

• the presence of concurrent infection or inflammation

• a known allergy to dexmedetomidine hydrochloride