Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis
Status:
Unknown status
Trial end date:
2017-08-01
Target enrollment:
Participant gender:
Summary
Cytokines such as such as TNF-a, IL-1, IL-6 correlate with the severity of
pancreatitis.Neuroendocrine pathways, such as the sympathetic nervous system or
parasympathetic nervous system, in turn, have some impact on the immune systems, through a-2
adrenoreceptor stimulation or the cholinergic anti-inflammatory pathway. The investigators
aim to use Dexmedetomidine Hydrochloride to decrease the activity of sympathetic nervous
system, thus relieve inflammation response.