Dexmedetomidine Infusion Effect on Hemodynamic Variables During Craniotomy

• Status: Completed
• Trial end date: 2021-01-26
• Target enrollment: 0
• Participant gender: All

Summary

There is no clear consensus among neuroanesthesiologists regarding which anesthetic regimen is optimal for craniotomy. Propofol and short-acting opioids (such as remifentanil, fentanyl, or sufentanil) are commonly used. However, use of opioids is associated with increased risk of respiratory depression and postoperative nausea and vomiting. Dexmedetomidine is a highly selective α2-adrenoreceptor agonist that has been considered as a useful and safe adjunct to anesthesia for various surgical procedures

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• American society of anesthesiologists- Physical status (ASA-PS) I and II patients,

• aged 18 to 65 years

• 70-80 kg

• both sexes

• undergoing elective supratentorial craniotomy for tumor resection

Exclusion Criteria:

• Patients under 18 years of age

• pregnancy,

• emergency surgery

• patients with a Glasgow Coma Score (GCS) less than 15.

• Those who had respiratory or cardiac dysfunction, renal insufficiency, liver impairment, or bleeding disorders