Dexmedetomidine Infusion Versus Oral Melatonin for Prevention of Intensive Care Delirium

• Status: Recruiting
• Trial end date: 2024-10-20
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to compare the effect of dexmedetomidine infusion and oral melatonin on preventing delirium in intensive care unit (ICU) patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tanta University
• Treatments: Dexmedetomidine; Melatonin

Criteria

Inclusion Criteria:

• Patients aged 21 years or older.

• Either gender.

• Healthy gastrointestinal function (patients tolerated oral medications by gavage or mouth).

• Richmond Agitation Sedation Scale (RASS) >-1.

• No basic delirium or mood changes before admission to intensive care unit(ICU).

Exclusion Criteria:

• Patient refusal.

• History of irreversible brain disease consistent with severe dementia.

• Patient admitted with a primary neurologic condition or injury (e.g., intracranial hemorrhage).

• Heart rate (HR) less than 50 beats/ min or second- third degree heart block in the absence of a pacemaker.

• Acute alcohol withdrawal requiring benzodiazepine administration.

• History of hepatic encephalopathy or end-stage liver disease (Child-Pugh class B or C).

• The expected duration of intensive care unit (ICU) stay less than 5 days.

• Inability to obtain informed consent.

• Pregnancy.

• Allergy to dexmedetomidine or melatonin.