Dexmedetomidine,Ketamine and Their Combination to Bupivicaine on Thoracic Epidural Analgesia

• Status: Completed
• Trial end date: 2018-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study investigate the effect of addition dexmedetomidine, ketamine or their combination to bupivacaine in thoracic epidural analgesia on acute postoperative pain after breast cancer surgery.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Bupivacaine; Dexmedetomidine; Ketamine

Criteria

Inclusion Criteria:

• Patients scheduled for modified radical mastectomy.

• ASA Physical status I, II and III.

Exclusion Criteria:

• Patients' refusal.

• Uncooperative patients & severe psychiatric illness (cannot evaluate their own pain intensity using visual analogue scale (VAS).

• Patients with history of drug allergy.

• severe renal or liver impairment, unstable ischemic heart disease

• Any contraindications to epidural analgesia (coagulopathy, recent -less than 1 week-treatment with thrombolytic or potent antiplatelet drugs as clopidogrel, and local infection).