Overview

Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Pain Relief

Status:
Recruiting
Trial end date:
2024-11-01
Target enrollment:
0
Participant gender:
All
Summary
The aim of the present study is to compare the analgesic efficacy of Dexmedetomidine, Ozone and Dexamethasone regional injection in carpal tunnel syndrome.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Tanta University
Treatments:
Dexamethasone
Dexmedetomidine
Criteria
Inclusion Criteria:

- Age from 20 to 60 years.

- Both sexes.

- Patients with ultrasonographic evidence of mild-to-moderate carpal tunnel syndrome
(CTS).

- Inclusion criteria will include numbness and pain in the median nerve (MN)
distribution persisting for minimum of 3 months , nerve conduction studies (NCS)
consistent with carpal tunnel syndrome (CTS) as per the American Association of
Neuromuscular and Electro diagnostic Medicine (AANEM) guidelines, and an median nerve
(MN) cross-sectional area (CSA)at the wrist >12 mm2 suggesting mild-to-moderate CTS
forms.

Exclusion Criteria:

- Patient refusal.

- Patients with severe symptoms and signs of CTS as identified per the American
Association of Neuromuscular and Electro diagnostic Medicine (AANEM) guidelines,[14]
as this is an indication for surgery,

- Patients who show improvement on medical treatment,

- Previous surgical or injectional CTS treatment,

- Pregnancy ,co existence of brachial plexopathy, or thoracic outlet syndrome,
polyneuropathy, radiculopathy and peripheral nerve lesion in upper limb.

- Severe cardiovascular disease

- Morbid obese patients (body mass index (BMI) of >35 kg/m2)

- Infection at site of injection.

- Bleeding diathesis.

- History of thyroid deficiency, uncontrolled diabetes mellitus , rheumatoid arthritis
and history of glucose-6-phosphate dehydrogenase (G6PD) deficiency

- History of Ozone or Dexmedetomidine allergy.

- End stage renal and hepatic disease.

- History of inflammatory joint , connective tissue disorders, , burns, any local tissue
contractures and history of wrist trauma.

- Patients who will not consent to completing The visual analogue scale (VAS) for pain
or nerve conduction study before and after injection.