Dexmedetomidine Pharmacokinetics During Continuous Renal Replacement Therapy (CRRT)

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine dexmedetomidine pharmacokinetics during continuous renal replacement therapy on critically ill patients.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helsinki University Central Hospital
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• Age ≥ 18

• Clinical need for sedation

• Acute kidney injury requiring renal replacement therapy (according to ICUs standard operating procedures)

Exclusion Criteria:

• Severe bradycardia (HR < 50/min)

• AV conduction block II-III (unless pacemaker installed)

• Severe hepatic impairment (bilirubin > 101 umol/l)

• Pregnancy or lactation

• Age < 18