Dexmedetomidine Pharmacokinetics in the Obese

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to characterize, using two different modeling approaches, one based on purely statistic concept and one using a more mechanistic analysis, the influence of body weight and composition on the pharmacokinetic of dexmedetomidine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pontificia Universidad Catolica de Chile
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• American Society Anesthesiologist classification I-III patients

• between 18 and 60 years of age

• scheduled for elective laparoscopic surgery

• obese patients with a BMI >35 kg m-2 (20 patients)

• non-obese patients (BMI 18.5-25 kg m-2)(20 patients)

Exclusion Criteria:

• known allergy to study drugs

• uncontrolled hypertension

• heart block greater than first degree

• those who had taken any drug acting in the central nervous system 24 h before surgery