Dexmedetomidine Premedication in Hypertensive Patients

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

Hypertensive patients' often severe hypotensive response after induction of anesthesia and excessive increase in blood pressure to stresses such as laryngoscopy, intubation, surgical incision and extubation. There are many publications in the literature of preoperative evaluation of patients with hypertension and perioperative treatment of hypertension but is not sufficient about anesthetic management of these patients. Purpose of our study, was to investigate the haemodynamic effects of dexmedetomidine and midazolam used for premedication in hypertensive patients relative to each other and according to the normotensive patients.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duzce University
• Treatments: Dexmedetomidine; Midazolam

Criteria

Inclusion Criteria:

• Normotensive

• Hypertension with stage 1 or 2

• Scheduled for myomectomy or hysterectomy operation

• Aged 40-60

• ASA I or II

• BMI is under 30 kg/m2

Exclusion Criteria:

• Untreated hypertension

• Users of ACE inhibitors as antihypertensive therapy

• History of severe cardiovascular disease, renal disease, diabetes mellitus, cerebrovascular disease

• An allergy to study drugs

• Difficult airway

• If the time more than fifteen minutes between the start of surgery and the induction

• If necessary blood transfusion was required