Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants

• Status: Completed
• Trial end date: 2021-01-31
• Target enrollment: 0
• Participant gender: All

Summary

This is a prospective randomized controlled trial comparing dexmedetomidine sedation with caudal anaesthesia, and general sevoflurane anaesthesia with caudal anaesthesia for inguinal herniotomies in neonates and infants below 3 months of age.

The investigators will compare the efficacy and adverse events associated with each of these techniques and neurodevelopmental outcomes of the infants in each group at 6 months and 2 years of age.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: KK Women's and Children's Hospital
• Collaborators: Duke-NUS Graduate Medical School; Singapore Institute for Clinical Sciences; Singhealth Foundation
• Treatments: Anesthetics; Dexmedetomidine; Sevoflurane

Criteria

Inclusion Criteria:

• Infants below 3 months of age ( corrected age 54 weeks) presenting for elective inguinal hernia repair in KKH.

Exclusion Criteria:

• History of prematurity younger than 28 weeks gestation,

• Requirement for CPAP greater than 6 cmH20 at time of surgery

• Significant cardiac pathology or cardiac conduction defects

• Unusually large hernia sacs

• Any contraindication for caudal anesthesia

• Surgeon refusal on account of anticipated prolonged or difficult surgery.