Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery

• Status: Recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes. The investigators hypothesize that dexmedetomidine supplemented analgesia in elderly patients after cancer surgery may help to maintain immune function and improve long-term outcomes, possibly by relieving stress and inflammatory response, improving analgesic efficacy and sleep quality, and reducing delirium incidence.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University First Hospital
• Collaborators: Affiliated Hospital of Hebei University; Beijing Chao Yang Hospital; Beijing Ditan Hospital; Beijing Shijitan Hospital, Capital Medical University; Beijing Tsinghua Chang Gung Hospital; Guizhou Provincial People's Hospital; Peking University International Hospital; Qingdao Municipal Hospital; Shanxi Provincial Cancer Hospital; The Second Affiliated Hospital of Air Force Medical University; The Third Xiangya Hospital of Central South University; Tianjin Hospital of ITCWM-Nankai Hospital; Zhongda Hospital Southeast University
• Treatments: Analgesics; Dexmedetomidine; Morphine

Criteria

Inclusion Criteria:

• Age >= 65 years, < 90 years;

• Scheduled to undergo surgery for primary solid organ cancer under general anesthesia, with an expected duration of surgery >=2 hours;

• Planned to use patient-controlled intravenous analgesia after surgery;

• Provide written informed consent.

Exclusion Criteria:

• Preoperative history of schizophrenia, epilepsy, parkinsonism or myasthenia gravis;

• Preoperative radio- or chemotherapy;

• Inability to communicate in the preoperative period because of coma, profound dementia or language barrier;

• Preoperative obstructive sleep apnea (previously diagnosed as obstructive sleep apnea, or a STOP-Bang score >= 3);

• Brain trauma or neurosurgery;

• Preoperative left ventricular ejection fraction < 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats per minute), or second-degree or above atrioventricular block without pacemaker;

• Severe hepatic dysfunction (Child-Pugh class C) or severe renal dysfunction (requirement of renal replacement therapy before surgery);

• ASA classification >= IV.