Overview
Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery
Status:
Active, not recruiting
Active, not recruiting
Trial end date:
2022-12-07
2022-12-07
Target enrollment:
0
0
Participant gender:
All
All
Summary
Delirium is common in the elderly after orthopedic surgery and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after orthopedic surgery, dexmedetomidine supplemented intravenous analgesia can reduce the incidence of delirium and improve the long-term outcomes.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Peking University First HospitalCollaborator:
Beijing Jishuitan HospitalTreatments:
Analgesics
Dexmedetomidine
Dsuvia
Sufentanil
Criteria
Inclusion Criteria:- Age ≥ 65 years but < 90 years;
- Scheduled to undergo total knee/hip replacement surgery, or spinal surgery;
- Planned to use patient-controlled intravenous analgesia (PCIA) after surgery.
Exclusion Criteria:
- Refuse to participate in this study;
- Preoperative history of schizophrenia, epilepsy, Parkinsonism, or myasthenia gravis;
- Inability to communicate in the preoperative period because of coma, profound dementia
or language barrier;
- Preoperative obstructive sleep apnea (diagnosed sleep apnea syndrome or a STOP-Bang
score ≥3 combined with a serum bicarbonate ≥28 mmol/L);
- Sick sinus syndrome, severe sinus bradycardia (< 50 beats per minute), or
second-degree or above atrioventricular block without pacemaker;
- Severe hepatic dysfunction (Child-Pugh class C);
- Severe renal dysfunction (requirement of renal replacement therapy before surgery);
- American Society of Anesthesiologists physical status >IV, or estimated survival ≤24
h.