Dexmedetomidine Versus Fentanyl for Sedation of Postoperative Mechanically Ventilated Neonates
Status:
Completed
Trial end date:
2017-08-30
Target enrollment:
Participant gender:
Summary
Newborn infants experience pain after surgical procedures,prevention and management of pain
in neonates is important due to its deleterious consequences. Fentanyl is a widely used
analgesic which promotes rapid analgesia,however, is not free of adverse effects including
chest wall rigidity, hypothermia, hypotension, respiratory depression and
tolerance.Dexmedetomidine is a selective α 2-adrenergic agonist can cause sedation,
anxiolysis, analgesia and minimal respiratory depression.Therefore, the objective of the
study is to evaluate the safety and efficacy of dexmedetomidine compared to fentanyl in
postoperative mechanically ventilated neonates.