Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the efficacy of dexmedetomidine versus propofol for prolonged sedation in trauma and surgical patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Tennessee Graduate School of Medicine
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• Patients were included in the study if they were 18 years of age or older,

• mechanically ventilated,

• placed on the institutional sedation protocol,

• expected to require sedation lasting 24 hours after randomization, and

• admitted to the TSICU and followed by the Trauma/Surgical Service.

Exclusion Criteria:

Patients were excluded for any of the following:

• 72 hours or greater since sedation protocol initiation,

• treatment per the institutional traumatic brain injury (TBI) protocol,

• concomitant continuous infusion of a neuromuscular blocking agent,

• heart rate less than 50 beats per minute,

• mean arterial pressure less than 55 mmHg despite fluid resuscitation and vasopressors, and

• use of other alpha-2 agonists within 24 hours of randomization.