Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery
Status:
Completed
Trial end date:
2019-07-01
Target enrollment:
Participant gender:
Summary
Investigators will assess the incidence and duration of postoperative delirium in patients
≥60 years old undergoing coronary artery bypass grafting (CABG), with/without valve surgery
(aortic and/or mitral) based on different regimens for postoperative sedation and analgesia.
Patients will receive either intravenous (IV) dexmedetomidine and IV acetaminophen or
standard postoperative management using IV propofol with morphine or hydromorphone. The
Confusion Assessment Method (CAM) will be used to assess delirium in these patients.
Investigators also seek to compare postoperative (48 hours) analgesic requirements in
patients with or without IV acetaminophen. Investigators will finally assess postoperative
cognition in post-surgical patients up to one year post-discharge using a cognitive
assessment scale.