Dexmedetomidine and Long-term Outcome in Elderly Patients After Surgery

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Delirium is a frequent postoperative complication. Its occurrence is associated with worse long-term outcomes. In a previous randomized controlled trial, prophylactic low-dose dexmedetomidine infusion during the early postoperative period decreased the incidence of delirium in elderly patients after surgery. The purpose of this 3-year follow-up study is to evaluate whether prophylactic low-dose dexmedetomidine infusion can improve the 3-year outcome in elderly patients recruited in the previous randomized controlled trial.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University First Hospital
• Collaborator: Peking University Third Hospital
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

Patients were included if they met all of the following criteria:

1. Age of 65 years or older;

2. Underwent elective noncardiac surgery under general anesthesia;

3. Admitted to ICU after surgery.

Exclusion Criteria:

Patients were excluded if they met any of the following criteria:

1. Preoperative history of schizophrenia, epilepsy, Parkinsonism or myasthenia gravis;

2. Inability to communicate in the preoperative period (because of coma, profound dementia or language barrier);

3. Brain injury or neurosurgery;

4. Preoperative left ventricular ejection fraction < 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats per minute), or second-degree or greater atrioventricular block without pacemaker;

5. Serious hepatic dysfunction (Child-Pugh class C);

6. Serious renal dysfunction (undergoing dialysis before surgery); or

7. Unlikely to survive for more than 24 hours.