Dexmedetomidine and Midazolam Nebulization as Sedation During Cesarean Delivery in Pre-eclampsia

• Status: Recruiting
• Trial end date: 2022-01-30
• Target enrollment: 0
• Participant gender: Female

Summary

Null hypothesis: There is no difference between the effects of nebulization of dexmedetomidine and midazolam as procedural sedation during cesarean delivery under spinal Anesthesia in pre-eclamptic parturients Alternative hypothesis: There is difference between the effects of nebulization of dexmedetomidine and midazolam as procedural sedation during cesarean delivery under spinal anesthesia in pre-eclamptic parturients

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zagazig University
• Treatments: Dexmedetomidine; Midazolam

Criteria

Inclusion Criteria:

• Age: 21-38 years old.

• Mild and moderate preeclampsia parturient.

• American Society of AnesthesiologistPhysical status II.

• Body Mass Index (BMI) (25-35kg/m²).

• Type of operations: elective cesarean section under spinal anesthesia.

• Written informed consent from the parturient.

Exclusion Criteria:

• Altered mental state.

• Women with known history of allergy to study drugs.

• Women with uncontrolled diabetes mellitus, bleeding, coagulation disorders, advanced hepatic, renal, cardiovascular, respiratory disease and neuropsychiatric disorders.

• Patients receiving anticonvulsants or antidepressants.

• Sever preeclampsia, intrauterine growth restriction or fetal compromise.