Dexmedetomidine and Propofol in the Treatment of Emergence Agitation

• Status: Unknown status
• Trial end date: 2021-08-30
• Target enrollment: 0
• Participant gender: All

Summary

1. This clinical research aims to compare the effects of dexmedetomidine and propofol on the treatment of emergence agitation in adult patients after general anesthesia.

2. Half of participants will receive dexmedetomidine while the other half will receive propofol when emergence agitation happens.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: RenJi Hospital
• Treatments: Anesthetics; Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• Adult patients aged 18-65 years old after general anesthesia

• with informed consent provided.

Exclusion Criteria:

• age younger than 18 years or older than 65 years;

• American Society of Anesthesiologists classification ≥Ⅲ;

• preoperative lung dysfunction(including pneumonia,atelectasis,adult respiratory distress syndrome,acute lung injury and so on);

• preoperative heart dysfunction(including sever cardiac coronary disease,unstable angina,LVEF≤30％，sick sinus syndrome，bradycardia:heart rate≤50bpm,second or third degree A-V block);

• history of mental disease;

• no informed consent provided;

• uncontrolled hypertension(baseline blood pressure:SBP≥160mmHg or DBP≥110mmHg);

• cancers;

• enrolled in other researches within 90 days;

• allergic to intervening medicine.

• BMI less than 18 or more than 30 kg/m2.