Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia

• Status: Not yet recruiting
• Trial end date: 2025-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this study is to compare two modes of labour epidural analgesia:

programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI), with patient controlled epidural analgesia (PCEA), using dexmedetomidine in addition to low-dose bupivacaine and through measuring the total volume of local anesthetic received through patient controlled epidural analgesia per hour

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assiut University
• Treatments: Bupivacaine; Dexmedetomidine

Criteria

Inclusion Criteria:

• Age 18 - 45 years

• Scheduled for normal vaginal delivery

• ASA physical status ӀI-IӀӀ.

• Singleton non-complicated pregnancy.

• At least 36 weak of gestation.

• Vertex presentation.

Exclusion Criteria:

• Patient refusal to epidural analgesia.

• History of cardiac, liver, or kidney diseases.

• History of allergy to amide local anesthetics or study medications.

• Any neurological problem.

• History of chronic opioid analgesic use.

• Any contraindication of regional anesthesia.

• Evidence of intrauterine growth restriction or fetal compromise.

• Failed or unsatisfactory analgesic block.

• Body mass index ≥40 kg/m2