Dexmedetomidine in Reducing Incidence of Emergence Agitation After Nasal Surgery
Status:
Not yet recruiting
Trial end date:
2023-04-30
Target enrollment:
Participant gender:
Summary
Various pharmacological interventions have been attempted previously to prevent postoperative
EA with variable results. These include use of opioids (9), propofol (10), midazolam (11),
ketamine (12), magnesium (13) and alpha-2 agonists like clonidine (14) and dexmedetomidine
(15). Dexmedetomidine have been used with different dosages and different timings of
administration with variable results and at the expense of major hemodynamic disturbances
(16, 17, 18,). The objective of this study was to investigate the role of single dose of
dexmedetomidine (0.5 mcg/kg) administered as 30 minutes infusion prior to extubation in
reducing the incidence and severity of EA and coughing on extubation.