Dexmedetomidine on Postoperative Delirium and Quality of Recovery in Geriatric Patients

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative agitation (hyperactive delirium) is common following major surgery(incidence was about 20% in our pilot study). Dexmedetomidine was related to a reduced delirium rate when comparing with midazolam in many clinical settings. It is not clear if dexmedetomidine is useful on reducing postoperative delirium. The hypothesis of present study: intraoperative application of dexmedetomidine (0.2ug/kg/h) is is effective (50% reduce) than placebo for reducing of early postoperative delirium and increase postoperative quality of recovery within 24 postoperative hours.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Huazhong University of Science and Technology
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• ASA physical status class I-III

• Aged 60 years or above

• Elective major surgery under general anesthesia

Exclusion Criteria:

• ASA-PS>=IV

• Aged under 60 yr old

• Body mass index (BMI) >30

• Neurologic disease

• Cardiac surgery and neurologic surgery

• Anticonvulsant drugs

• Chronic analgesics intake

• Participating in the investigation of another study