Dexmedetomidine-propofol-remifentanil Anaesthesia and Reactivity to Noxious Stimuli

• Status: Completed
• Trial end date: 2011-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Dexmedetomidine acts at central nervous system (specifically: at locus caeruleus), providing sedative and analgesic effects. It is widely used in intensive care. Surgery-related interventions elicit arousal ('nociceptive') reactions. The effects of dexmedetomidine on the neurophysiological signs of arousal are studied in surgical patients. Brain waves, electrocardiogram, Entropy Index, Bispectral Index, and fingertip pulse waves are recorded and analyzed later on. The course of anaesthesia and surgery are recorded.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Arvi Yli-Hankala
• Treatments: Anesthetics; Dexmedetomidine; Propofol; Remifentanil

Criteria

Inclusion Criteria:

• males or females giving informed consent

• age range 18-70 years

• elective surgery: laparoscopy, laparotomy, breast surgery

• general anaesthesia

• ASA classification 1 or 2

Exclusion Criteria:

• pregnancy

• body mass index 30.1 or more

• diseases affecting CNS, autonomic nervous system, heart, heart rate, or circulation

• chronic use of drugs affecting CNS, autonomic nervous system, heart, heart rate, or circulation; except antihypertensives, which are acceptable in this study

• chronic use of clonidine

• serious psychiatric disease or condition

• overuse of alcohol

• use of illicit drugs

• unability of understand, read or use Finnish language