Dexmedetomidine vs Midazolam on Resting Energy Expenditure in Critically Ill Patients

• Status: Completed
• Trial end date: 2018-03-15
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare the effect of dexmedetomidine on resting energy expenditure in relation to the midazolam in critically ill patients using indirect calorimetry

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Treatments: Dexmedetomidine; Fentanyl; Midazolam

Criteria

Inclusion Criteria:

• The study will be designed to recruit 30 critically-ill patients who will be admitted to the surgical ICU for ventilatory support and will be expected to continue for 2 days or longer.

Exclusion Criteria:

• Age < 18 years old.

• Pregnant patient.

• Serious central nervous system pathologies (traumatic brain injury, acute stroke, uncontrolled seizures).

• Patient who will require fraction of inspired oxygen more than 0.6.

• Air leak from the chest tube.

• Patient with body temperature > 39 Celsius.

• Acute hepatitis or severe liver disease (Child-Pugh class C).

• Left ventricular ejection fraction less than 30%.

• Heart rate less than 50 beats/min.

• Second or third degree heart block.

• Systolic pressure < 90 mmHg despite of infusion of 2 vasopressors.

• Patients with known endocrine dysfunction.

• Patient with hypothermia

• Patient on Positive end expiratory pressure more than 14 cmH2o