Dexmedetomidinine in the Prevention of Postoperative Delirium in the Intensive Care Unit After Cardiac Surgery

• Status: Recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a prospective, randomized, single blinded, controlled clinical trial designed to compare the clinical effects of sedation with dexmedetomidine versus propofol in patients undergoing cardiac surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Novi Sad
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• patients undergoing open heart surgery with the use of cardiopulmonary bypass (including coronary artery bypass grafting, valve repair/replacement, and combined)

• left ventricular ejection fraction (LVEF) >40%.

Exclusion Criteria:

• preoperative atrial fibrillation

• previous history of interventionally treated arrhythmias

• second and third degree atrioventricular block

• bradycardia with heart rate ≤50/min

• pacemaker

• renal or hepatic insufficiency

• emergency procedures

• history of serious mental illness, delirium, and severe dementia