Diabetes Intervention Trial With Vitamin D in Subjects of Nordic and Sub-Indian Ethnicity

• Status: Unknown status
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this 6 months study is to evaluate the metabolic effects of 400.000-600.000 IU of vitamin D supplementation in subjects with type 2 diabetes and hypovitaminosis D. The main hypothesis is that subjects with low levels of 25-OH-vitamin D will benefit from supplementation with cholecalciferol in sufficient doses to optimize serum levels.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Aker
• Collaborator: University of Oslo
• Treatments: Cholecalciferol; Ergocalciferols; Insulin; Vitamin D; Vitamins

Criteria

Inclusion criteria:

1. Moderate (S-25OHD 25-50 nmol/l) to severe (S-25OHD < 25 nmol/l) vitamin D deficiency measured at Visit 1.

2. Patients with type 2 diabetes, including drug naïve subjects, subjects using oral anti-diabetic medication and subjects on insulin treatment. All medication must be in stable doses during the 4 week lead-in period.

3. HbA1c < 11 % at Visit 1.

4. Able to communicate in Norwegian.

5. Men and women ≥ 18 years.

6. Norwegian or South Asian ethnicity.

7. Women of childbearing potential (WOCBP) must be using an adequate method of contraception to avoid pregnancy throughout the study. All WOCBP must have negative serum or urine pregnancy test at enrollment, randomization, titration visit and final study assessment.

8. Antihypertensive medication, lipid lowering drugs, oral contraceptives, hormone replacement therapy, multivitamin supplements and nutritional supplements are allowed if the subjects adhere to the same regimen during the study

Exclusion Criteria:

1. Subjects not having type 2 diabetes.

2. SBP ≥ 160 or DBP ≥ 95 at Visit 1.

3. Significant renal disease or chronic renal impairment, GFR< 30 ml/min.

4. Significant liver disease or ASAT or ALAT >3x UNL.

5. Malignancy during the last five years.

6. Hypercalcemia at Visit 1.

7. A history of kidney stone disease

8. WOCBP unwilling or unable to use an acceptable method to avoid pregnancy.

9. Pregnant or breastfeeding women.

10. Chronic inflammatory disease in active phase

11. Long term (>2 weeks) use of corticosteroids last 3 months

12. Mental condition (psychiatric or organic cerebral disease) rendering the subject unable to understand the nature, scope and possible consequences of the study.

13. Drug or alcohol abuse.

14. BMI > 45 kg/m2 or bariatric surgery (<5 years).

15. Anemia

16. Cardiovascular disease (myocardial infarction, unstable angina pectoris or stroke) during the last 6 months.

17. Any medical condition that in the judgment of the investigator would jeopardize the subject's safety or evaluation of the study drug for efficacy and safety.