Diagnostic Study of Quantitative Imaging and Spectroscopy in Patients With Multiple Sclerosis
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Determine by quantitative magnetic resonance imaging measurements the change
in the total volume of brain parenchyma as well as its gray and white matter, T2 and enhanced
T1 lesion volume, and the magnetization transfer ratio histogram parameters, and correlate
these measurements with clinical measures of disability in patients with multiple sclerosis.
II. Measure the quantity of whole brain N-acetylaspartate in patients with multiple sclerosis
and compare these values to those from age matched controls.
III. Determine the correlation between specific neuropsychological tests which assess global
cognitive functioning and the quantitative measurements taken in these patients in this
study.