Diagnostics of Chronic Endometritis in Infertility
Status:
Completed
Trial end date:
2023-10-30
Target enrollment:
Participant gender:
Summary
Chronic endometritis (CE) is characterized by the presence of atypical plasma cell
infiltrates (CD138 positive) in the endometrial stroma. Recent analyzes suggest that CE
adversely affects fertility by reducing endometrial receptivity, impairing decidualization
and uterine contractility, thus increasing the risk of recurrent pregnancy loss and
implantation failure. It is likely that a significant proportion of idiopathic infertility
cases are due to CE. The diagnosis of CE is a challenge because the clinical examination and
transvaginal ultrasonography are considered non-specific. The recent scientific research has
been aimed at identifying hysteroscopic CE diagnostic criteria and establishing the
compatibility of ultrasonographic, hysteroscopic, histopathological (including the use of
immunohistochemical testing with antibodies against human CD138) and microbiological
diagnoses. Preliminary literature results suggested that successful treatment of CE with
antibiotics could improve live birth rates.