Diastolic Heart Failure Management by Nifedipine

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with heart failure with preserved ejection fraction have a equally high risk for mortality and re-hospitalization as those with reduced ejection fraction. Effective management strategies are critically needed to be established for this type of heart failure. These patients have more hypertensive and ischemic etiology than those with reduced ejection fraction. The investigators hypothesis is that Ca channel blocker nifedipine can improve the heart failure clinical composite response endpoint compared with the conventional treatment in patients with heart failure with hypertension and/or coronary artery disease and preserved ejection fraction (>=50%) by echocardiography. This study is multi-center, prospective, randomized, open-label, and blinded-endpoint design.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Demand Investigators
• Treatments: Nifedipine

Criteria

Inclusion Criteria:

1. 20 years and older

2. Heart failure with history of hypertension and/or coronary artery disease

3. LVEF > or = 50% on echocardiography

Exclusion Criteria:

1. Valvular heart diseases with significant regurgitation and/or stenosis

2. Hypertrophic cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and active myocarditis

3. Constrictive pericarditis

4. Cardiogenic shock

5. Planned coronary artery bypass grafting or percutaneous coronary intervention within 3 months

6. History of acute coronary syndrome or stroke within 3 months

7. Pregnancy or breastfeeding

8. Hypersensitivity or contraindication to nifedipine

9. Inability to obtain informed consent

10. Any conditions not suitable for the participation in this trial judged by the investigator