Diazoxide In the Management Of Hypoglycemic Neonates
Status:
Unknown status
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
Diazoxide is an oral hyperglycemic medication. Diazoxide has been proven effective for
treating hypoglycemia in infants and children with some types of persistent hyperinsulinemic
hypoglycemia. The mechanism of action results in decreased insulin secretion. One of the
causes of hypoglycemia in infants of diabetic mothers occurs due to a transient
hyperinsulinemic state postnatally. The investigators have clinical experience and success
using diazoxide in their unit for patients with hypoglycemia not adequately managed with
intravenous (iv) dextrose and enteral supplementation. In this randomized controlled study
the investigators expect that by using diazoxide as the initial treatment for infants of
diabetic mothers with asymptomatic hypoglycemia (blood glucose of 2.5 to 2.0mmol/L), the
investigators will be able to decrease the number of infants requiring an intravenous by at
least thirty percent.