Overview

Dichotic Listening as a Predictor of Medication Response in Depression

Status:
Completed

Trial end date:
2011-08-01

Target enrollment:
0

Participant gender:
All

Summary

This study will recruit 100 depressed patients to test whether the previous finding of an association between treatment response (with treatment groups including placebo, imipramine, and fluoxetine) and preferences of hemispheric laterality in perceptual processing are also found with a different type of commonly used anti-depressant, bupropion.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

New York State Psychiatric Institute

Treatments:

Bupropion
Citalopram
Dexetimide
Imipramine

Criteria

Inclusion Criteria:

1. Ages between 18-65

2. Meets Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) criteria for current
Major Depression, Dysthymia or Depression Not Otherwise Specified

Exclusion Criteria:

1. Known Hearing impairment

2. Active suicidal ideation (history of suicide attempts will be evaluated on a case by
case basis).

3. Hamilton Rating Scale for Depression (HAMD), 21-item total score >20

4. Current (past 6 months)alcohol and/or drug abuse or dependence

5. Medical condition likely to require intervention contraindicated with study medication
(e.g., known arrhythmia likely to be exacerbated by Imipramine)

6. Bipolar I

7. Psychosis

8. Non-response to adequate trial of study medication (i.e., > or = 4 weeks on > or =
bupropion 300mg/d, escitalopram 30mg/d, or imipramine 200mg/d)

9. Premenopausal women not using known effective birth control

10. Not currently depressed (whether considered due to current treatment or not)

11. History of seizure, seizure disorder, anorexia nervosa, or bulimia

12. Left-handed -