Dicloxacillin: Clinical Relevance of Drug-drug Interactions by Induction of Drug Metabolism.

• Status: Completed
• Trial end date: 2017-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

This trial is conducted as a cocktail-study namely an open-label, randomized, two-sequence, two-period crossover, cocktail study where a combination of cocktail-drugs is used to illustrate whether or not, or to what degree dicloxacillin affects the level of activity of the 5 most important CYP enzymes and therefore plays a potentially decisive role in serious drug-drug interactions.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Per Damkier
• Treatments: Anti-Bacterial Agents; Dicloxacillin

Criteria

Inclusion Criteria:

• Are you in a general healthy condition?; questions asked; Are you healthy in general? 2; Do you have any chronic diseases? 3; Are you taking any medications regularly? 4, Are you taking any medications periodically . 5; Are you taking nutrition supplements, "nature-medicine" or over-the-counter drugs

• BMI; range; 18,5-29,9 kg/m2

• eGFR(estimated glomerular filtration rate), ALAT(alanine aminotransferase), bilirubin, hæmoglobin og HbA1c, should be within normal limits or without clinically significantly deviation from these.

• Non-Smoker

Exclusion Criteria:

• Hypersensitivity to applied medications. Known allergy to penicillin or type 1-reaction to cefalosporins.

• Known allergy to sulfonamides

• Clinically relevant intake of receipt-required medication, over-the-counter medication or nutritional supplements.

• Chronic or daily intake of alcohol.

• Participation in other Intervention-studies