The investigators are studying the effects of exposure to diesel exhaust on lung inflammation
in the presence and absence of an inhaled corticosteroid. Although data is mixed, studies
show that asthmatics have increased lung inflammation and worse symptoms during periods of
higher air pollution despite taking their anti-inflammatory corticosteroid medication. One
possible reason is that air pollution exposure may decrease the ability of corticosteroids to
combat inflammation.
To test this volunteers will inhale either a placebo or a corticosteroid, before sitting in
an exposure booth for 2 hours breathing either filtered air or diluted diesel exhaust.
Samples will be collected before and after exposure to analyze the effects of budesonide and
diesel exhaust exposure.
Phase:
Phase 4
Details
Lead Sponsor:
University of British Columbia
Collaborators:
AllerGen NCE Inc. Canadian Institutes of Health Research (CIHR)