Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated
diluted diesel exhaust inhalation on vascular function. To examine role of adrenergic system
a trial of alpha-blocker terazosin is also used. Each participant completes four study
sessions, separated by at least three weeks: 1) Diesel exhaust inhalation (DE, controlled at
300 micrograms/cubic meter for two hours) and terazosin (2 mg prior to inhalation exposure);
2) DE plus placebo (matched for terazosin); 3) filtered air plus terazosin; and 4) filter air
plus placebo. The investigators assess outcomes of blood pressure, forearm brachial artery
ultrasound, and plasma measures of endothelial activation. The investigators hypothesize that
DE exposure will be associated with increased blood pressure, decreased brachial artery
diameter, and increased circulating endothelins, and that these effects will be attenuated by
terazosin administration.
Phase:
N/A
Details
Lead Sponsor:
University of Washington
Collaborators:
Environmental Protection Agency (EPA) National Institute of Environmental Health Sciences (NIEHS)