Diet Quality, Pecans, and Cardiometabolic Health

• Status: Withdrawn
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

A three-period, randomized, crossover controlled feeding trial will be conducted to examine the effect of including 2 oz./day of pecans, as a snack, in a diet representative of average American intake, compared to a diet representative of average American intake devoid of nuts, and a healthy dietary pattern including 2 oz./day of pecans on markers of peripheral vascular health, lipids and lipoproteins, blood pressure, and glycemic control.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Penn State University

Criteria

Inclusion Criteria:

• BMI ≥25 and ≤40 kg/m2

• ≥ 1 criterion for metabolic syndrome (i.e. waist circumference ≥ 94 cm men or ≥80 cm women; triglycerides ≥150 mg/dL; HDL ≤ 40 mg/dL men or ≤50 mg/dL women; systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg; fasting plasma glucose ≥100 mg/dL) at screening.

• non-smoking

Exclusion Criteria:

• Current tobacco use or use within the previous 6 months

• Diagnosed diabetes or fasting glucose levels > 126 mg/dL at screening

• Systolic blood pressure >160 mm Hg or diastolic blood pressure > 100 mm Hg at screening.

• Use of anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics in the previous month

• History of a cardiovascular event (heart attack, revascularization, stroke), or heart failure, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis

• Use of supplements and botanicals known to affect study outcomes (e.g. psyllium, fish oil, soy lecithin, and phytoestrogens) and not willing to cease for the duration of the study

• Pregnancy, lactation or planning to become pregnant

• Consumption of >14 alcoholic drinks/week

• Intolerance/allergy/sensitivity to foods included in the study menus