Different Doses and Duration of Low Molecular Weight Heparin (Parnaparin)in Superficial Vein Thrombosis

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The optimal treatment of superficial venous thrombosis (SVT) is still uncertain. Though low molecular weight heparin (LMWH) is considered the treatment of choice, studies conducted so far do not give clear indications of the optimal dose and duration of treatment. This study aims to evaluate whether an intermediate therapeutic dose of LMWH (parnaparin) is more effective than a prophylactic dose and also to assess whether 10 rather than 30 days are sufficient for treatment.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna; St. Orsola Hospital
• Treatments: Dalteparin; Heparin; Heparin, Low-Molecular-Weight; Parnaparin

Criteria

Inclusion Criteria:

• Weight > 50 kg and less than 110 kg

• SVT of the grand saphenous vein for at least 4 cm

• SVT of the small saphenous vein for at least 4 cm

• Collateral SVT of the large saphenous vein of the thigh for at least 4cm

Exclusion Criteria:

• SVT of the grand saphenous vein reaching the saphenofemoral cross (within 3 cm)

• SVT of the small saphenous vein reaching the saphenopopliteal cross

• Documented proximal or distal DVT or pulmonary embolism

• SVT secondary to sclerotherapy

• Pregnancy and puerperium

• uncontrolled arterial hypertension (Systolic pressure > 180 mmHg and diastolic pressure > 110 mmHg)

• Active peptic ulcer

• Bacterial endocarditis

• Stroke in the previous 3 months

• Haemorrhagic diathesis

• Thrombocytopenia (platelets < 100,000/ µL)

• Hypersensitivity to heparin or history of thrombocytopenia induced by heparin

• Creatinine > 2 mg% (> 180 µmol/L)

• Heparin therapy (any dose) or anticoagulant therapy for longer than the previous 72 hours

• In-hospital development of SVT

• Previous saphenectomy by any method

• Surgery in the previous 30 days

• Serious liver disease

• Use of dextran, mannitol, thrombolytic treatment, chronic use of NSAID and cortisone-based drugs.

• Active cancer or under chemotherapy or radiotherapy

• Thrombectomy of superficial vein involved

• Refusal to give informed consent