Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics

• Status: Completed
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose. The hypothesis is that different dyskinesias (dystonia, chorea) correlate to different levels of levodopa concentrations, as detected in plasma.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Uppsala University
• Collaborators: Swedish Parkinson's Disease Foundation; Swedish Society for Medical Research
• Treatments: Carbidopa; Carbidopa, levodopa drug combination; Levodopa

Criteria

Inclusion Criteria:

• Clinical diagnosis of idiopathic Parkinson's disease

• Ongoing treatment with Duodopa

• Occurrence of dyskinesias, difficult to manage

• Age 30-90 years

• Hoehn & Yahr stage 3-5 at worst

Exclusion Criteria:

• Treatment with dopamine agonist or glutamate antagonist

• Dementia

• Psychosis

• Treatment with typical neuroleptics