Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University

• Status: Active, not recruiting
• Trial end date: 2021-09-15
• Target enrollment: 0
• Participant gender: All

Summary

Cardiac surgery is associated with post-operative pain which is one of the major problems and remains one of the most controversial issues. Inadequate pain control after cardiac surgery increases the incidence of development of many complications. Intravenous opioids are commonly used for postoperative analgesia either on demand "physician or nurse-controlled" or patient -controlled.

Multimodal opioid sparing analgesia has become frequently used, These techniques can be achieved with Dexmedetomidine, low-dose ketamine and magnesium.

The study hypotheses that control of perioperative quality of pain with opioid sparing medications may improve analgesia and patient outcome.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mansoura University
• Treatments: Dexmedetomidine; Fentanyl; Ketamine; Magnesium Sulfate; Propofol

Criteria

Inclusion Criteria:

• Adult patients of both gender,

• Aged above 18 years

• American Society of Anesthesiologists (ASA) physical status II & III,

• Body mass index less than 40 kg/m2

• Scheduled for any cardiac procedure with median sternotomy that require cardiopulmonary bypass at Cardiothoracic Surgical Department, Mansoura University Hospitals.

Exclusion Criteria:

• Patients with pulmonary dysfunction or chronic obstructive pulmonary diseases

• Acute or unstable angina

• Previous cardio-thoracic surgery

• Emergency surgery

• Left ventricular ejection fraction less than 40%

• Dysrhythmia or pacemaker

• Major hepatic or renal dysfunction

• Need for re-exploration, uncontrolled diabetes (HbA1c > 8.5)

• Neurological deficit

• Hyper-magnesemia