Different Protocols in Ovarian Stimulation in Intracytoplasmic Sperm Injection Cycles
Status:
Not yet recruiting
Trial end date:
2021-03-01
Target enrollment:
Participant gender:
Summary
During assisted reproduction technology treatments like in vitro fertilization, some patients
give a poor ovarian response to controlled ovarian hyperstimulation. The European Society of
Human Reproduction and Embryology consensus defined poor response to ovarian stimulation
during in vitro fertilization with Bologna criteria.
Bologna criteria: At least two of the following three features must be present:
(i) Advanced maternal age (≥40 years). (ii) Previous Poor responders (≤3 oocytes with a
conventional stimulation protocol).
(iii) An abnormal ovarian reserve test Most controlled ovarian hyperstimulation regimens
currently used for expected poor responders are based on using a high daily dose (300- 450
IU/day) of exogenous gonadotropins. Giving a high gonadotropin dose obviously increases the
cost of in vitro fertilization, a consequence that would be acceptable if paralleled by an
improvement in in vitro fertilization outcome. Unfortunately, however, the available data
suggest that increasing the daily gonadotropins dose may increase the number of retrieved
oocytes, but not the final success rate of in vitro fertilization.