Different Schemes of Magnesium Sulfate for Preeclampsia

• Status: Terminated
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Eclampsia is an obstetric emergency capable of prophylaxis. To prevent and control seizures, there is no doubt that the magnesium sulfate (MgSO4) is the ideal drug. However, there are still questions regarding its use and dose. The scheme and the optimal time of administration remain to be elucidated. The objective of this trial is to compare the effectiveness and safety of intravenous magnesium sulfate in the maintenance phase 1g / h versus 2 g / h to prevent eclampsia in pregnant and postpartum women with severe preeclampsia (pure or superimposed).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Materno Infantil Prof. Fernando Figueira
• Treatments: Magnesium Sulfate

Criteria

Inclusion Criteria:

• Severe Preeclampsia (pure and superimposed)

Exclusion Criteria:

• Eclampsia before administration of the loading dose of MgSO4 ;

• Use of other medications or illicit drugs that may interfere with maternal hemodynamics;

• Contraindications to the use of magnesium sulfate: known hypersensitivity to the drug, oliguria with urine output below 25 ml per hour or anuria (urine output absent) and myasthenia gravis.

• Use of mechanical ventilation