Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Giving chemotherapy before a donor stem cell transplant helps stop the growth of
cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem
cells. When the healthy stem cells from a donor are infused into the patient they may help
the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets.
Sometimes the transplanted cells from a donor can make an immune response against the body's
normal cells. Giving cyclosporine, methotrexate, leucovorin, and antithymocyte globulin
before and after transplant may stop this from happening. It is not yet known which treatment
regimen is most effective in treating acute leukemia.
PURPOSE: This randomized clinical trial is studying how well different therapies work in
treating infants with newly diagnosed acute leukemia.
Phase:
N/A
Details
Lead Sponsor:
Dutch Childhood Oncology Group
Collaborators:
Associazione Italiana Ematologia Oncologia Pediatrica Australian and New Zealand Children's Oncology Group BFM Austria BFM Germany CLCG France Belgium Portugal COALL Germany CORS Monza Italy CPH, Czech republic DFCI consortium USA FRALLE France Hong Kong MD Anderson USA NOPHO Scandinavian countries PINDA, Chile PPLLSG Poland Seattle USA SJCRH USA UKCCSG United Kingdom