Diffusion Length of Local Anesthetics in the Subparaneural Space and Duration of Analgesia

• Status: Not yet recruiting
• Trial end date: 2025-07-29
• Target enrollment: 0
• Participant gender: All

Summary

Ultrasound-guided popliteal sciatic nerve block is a widely practiced technique to provide anesthesia or analgesia for below-knee surgeries. One study named the space between paraneural sheath and epimysium of sciatic nerve as the subparaneural space. It has been reported that injection into the subparaneural space has several advantages (improved the quality of the sensory block and resulted in a longer block duration) over conventional perineural injection. The investigators conducted this prospective randomized study to test the hypothesis that, during ultrasound-guided single popliteal sciatic nerve block, diffusion length of local anesthetics in the subparaneural space could predict anesthetic effect and duration of analgesia. The results of this study will develop a novel indicator to facilitate personalized medicine for patients receiving sciatic block.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital of Ningxia Medical University
• Treatments: Ropivacaine

Criteria

Inclusion Criteria:

• scheduled for elective below-knee surgery under general anesthesia combined with peripheral nerve block were included. Their physical status was rated I to II by the criteria of the American Society of Anesthesiologists (ASA).

Exclusion Criteria:

• clinically significant coagulopathy, infection at the injection site, allergy to the local anesthetics, severe cardiopulmonary disease (NYHA ≥III), a body mass index > 35kg/m2, diabetic or other neuropathy, prior surgery in the popliteal region, or receiving opioids for chronic analgesic therapy.