Diindolylmethane in Treating Patients With Abnormal Cervical Cells

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of diindolylmethane, a substance found in cruciferous vegetables, may keep cervical intraepithelial neoplasia or cervical cancer from forming.

PURPOSE: This randomized phase III trial is studying diindolylmethane to see how well it works compared to a placebo in treating patients with abnormal cervical cells.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Barts and the London School of Medicine and Dentistry
• Treatments: 3,3'-diindolylmethane

Criteria

DISEASE CHARACTERISTICS:

• First mildly dyskaryotic Pap smear or a second borderline Pap smear taken within the Cervical Screening Wales program

• Patients under surveillance following treatment for high-grade cervical intraepithelial neoplasia are not eligible

• No clinical suspicion of a concurrent invasive cervical cancer

PATIENT CHARACTERISTICS:

• No invasive cancer within the past 3 years

• No known HIV positivity

• Not pregnant or nursing

• Not planning to become pregnant within the next 6 months

PRIOR CONCURRENT THERAPY:

• No concurrent immunosuppressive drugs, warfarin, or theophylline

• No concurrent proton pump inhibitor drugs for ulcer or reflux disease (i.e., rabeprazole, esomeprazole magnesium, lansoprazole, omeprazole, or pantoprazole sodium)