Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers

• Status: Completed
• Trial end date: 2017-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Digital ulcers are one of the most prevalent complications of scleroderma (systemic sclerosis). There can be found few surveys on effect of topical agents on healing process of the ulcers. Thus, the aim of this study is to assess and compare the effects of topical diltiazem on SSc digital ulcers versus topical nitroglycerin.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mohammad Ali Nazarinia
• Collaborator: Shiraz University of Medical Sciences
• Treatments: Diltiazem; Nitroglycerin; Petrolatum

Criteria

Inclusion Criteria:

• Having the criteria of LeRoy.

• Having ages between 20-70 years old

• Having at least one active digital ulcer

Exclusion Criteria:

• Having co-morbid diseases such as diabetes, thyroid and cardiovascular diseases

• Being smoker, opium addict or alcohol abuser

• Ones received inhaled or oral prostanoid in last 3 months, phosphodiesterase inhibitors except for intermittent treatment of erectile dysfunction in last 1 month and the ones received antibiotics 2 weeks prior to the study

• The ones with moderate to severe hepatic impairment or increase in aminotransferase levels more than 3