Diosmin for Treatment of Delayed-onset Muscle Soreness (DOMS)
Status:
Recruiting
Trial end date:
2024-05-01
Target enrollment:
Participant gender:
Summary
The potential benefits of exercise for the treatment of chronic inflammatory diseases and
pain have been well documented in the scientific literature. Psychiatric, neurological,
metabolic and cardiovascular diseases are examples of conditions that impact the health and
quality of life of the population. Due to the effects provided by exercise, it can modify the
natural course of these diseases. This concept is important to justify the efforts made by
government bodies committed to promoting exercise, such as the WHO. However, the habitual
practice of physical activity following the primary guidelines may be hampered by some
factors, including those that support the physiological repercussions of exercise on the
body, such as muscle pain. In this sense, an important complicating factor such as
delayed-onset muscle soreness (DOMS), present in the post-exercise recovery period, can
impair adherence and permanence in physical activity programs, thus representing a
considerable barrier to exercise promotion. They can also severely impair the performance of
high-level athletes. Flavonoids, present in plants, but also in foods of the human diet, are
known to have several biological properties, including analgesic, anti-inflammatory, and
antioxidant effects. Currently, there are still few studies that have evaluated the effects
of flavonoids on the development and evolution of DOMS in humans.