Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids

• Status: Completed
• Trial end date: 2018-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To access the efficacy of adding diphenhydramine as adjunct to improve sedation and to reduce the amount of standard sedatives used during colonoscopy in patients on chronic opioids.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Oklahoma
• Treatments: Diphenhydramine; Hypnotics and Sedatives; Promethazine

Criteria

Inclusion Criteria:

• Patients aged 18-64 years undergoing screening, surveillance, diagnostic and therapeutic colonoscopy

• Patient on chronic opioids defined as at least 5 mg of morphine or its equivalent at least 3 days per week for more than 3 months

Exclusion Criteria:

• Inability to execute informed consent

• Allergy to Diphenhydramine, fentanyl or midazolam

• Known or suspected pregnancy

• Endoscopic procedure without sedation

• Patient scheduled to have other endoscopic procedures on the same day

• Prior alimentary tract surgery

• Severe cardiopulmonary disease (ASA IV)

• Monoamine Oxidase Inhibitors (MOI) use within 2 weeks of procedure